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Antibe Therapeutics Inc(Pre-Merger) ATBPF

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.


GREY:ATBPF - Post by User

Post by Pragmatiston Feb 20, 2021 3:25am
503 Views
Post# 32617701

Next NR

Next NR
My guess is Oten IND.  Maybe this weekend; next week or two at worst.
 
At Biopub, Dan said that the company would be submitting the IND shortly after Christmas.  Seems to have stretched this out a bit wrt sho-o-o-o-ortly.  But definitely imminent.
 
From the corporate update, 11 Jan: 
 
"As planned, we will be submitting otenaproxesul’s IND (“Investigational New Drug”) application to the U.S. FDA within weeks." 
 
These two posts suggest sooner rather than later.
 
INDs are normally submitted prior to the commencement of clinical trials. ATE is well beyond this by light years. It has completed  PH 2  under Health Canada auspicies. But it needs to get into the FDA system.
 
I think that that the company is attempting to combine the requisite IND requirements with the customary post Ph2 accomplishments,  prior to securing FDA concurrence for PH 3. Makes sense given where the company is at this stage. 
 
My prediction:  IND review: slam dunk: FDA post PH 2 meeting : slam dunk. How could if be otherwise in consideration of what has been accomplished to date.
 
Just a thought!
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