scarlet1967 wrote: I agree with Palinc moving forward BioAtla is a phase 1/starting phase 2 cancer company, their CAB ADC programs range are from completed phase 1 to preclinical/ initiating phase 1 ADC programs.
They licensed their BA3071 (a phase 1 ADC program) to BeiGene with offices in China, US, Europe... and received $25 million in upfront payments & reimbursement, they are also eligible to receive up to $225.5 million for subsequent regulatory and development milestones.
They are in collaboration with Himalaya Therapeutics who has the exclusive license from BioAtla to develop and commercialize several specific CAB candidates for the Greater China, Hong Kong, Macau and Taiwan, including two Phase 1/2 clinical stage assets, as well as worldwide rights to two additional preclinical drug candidates.
They launched IPO on December 16th raising over $217 MM in gross proceeds with $383 million raised to date.
It looks like they have given away the rights of all their ADCs apart from one entering phase 2.
They are purely R&D, no commercial drugs with a market cap at $1.7 billion. They also seem to have successfully managed to find global partners. I am not sure what their financial assets are as they just launched. To me it shows how a proactive company manages to progress with their R&D programs yet get the attention of bigger biotechs which is the ideal scenario for THTX.
Wino115 wrote: One of these was labeled wrong -- it's BioAtla. This company just went public and has a market cap of $1.6bil. It's a cancer stock -- they make a biologic that attaches to tumors based on the acidity difference of the membrane and then switches on. So it's sort of like a homing device that allows for other drugs and vehicles (ADCs, CAR-Ts, others) to just attache to the tumor and not healthy tissues based on "switching" it on. They call them "Conditionally Active Biologics", CABs.
So a way to have much lower toxicity and treat for longer. Sound familiar?
They're leading drugs are in Phase 2's and target things like sarcoma, ovarian, etc.. The rest is all pre-clinical or about to go Phase 1. So really, they just have two trials just entering Phase 2 and 3-4 behind that. Each is a different drug or mechanism attached to their CAB.
The Soleus guys are on the board. So lends a bit more to the thought that these guys really do know the cancer space quite well and have chosen to invest in the SORT1+ platform. Credibility there with that. I notice the other big holders of BioAtla are Baker Brothers, HRM and assorted other healthcare specialists. Now they'll have SORT1+ to chat about at their cocktail parties!
Wino115 wrote: I think Spatrap mentioned ESSA PHarma (EPIX) a few weeks ago (prostate cancer drug). That's one of Soleus larger holdings. It's up 5x since summer. Others are Biotla (top holding Dec20), Lantheus, Iveric bio, C4 Therapeutics, Alpine Immune.
Looks like they manage around $700mil in US fund and positions vary from $10-$40mil.