RE:RE:Answer about the linkerAnother thing I learned in all my readings yesterday is that taxanes in general and docetaxel in particular is almost insoluble in water. The formulation for the drug contains 13% ethanol and polysorbate 80, an emulsifier. So another advantage of a PDC is to eliminate the need for dissolving agent for the drug since once chemically linked to the peptide, it's the overall solubility of the molecule that comes into play and the PDC molecule is soluble in water or saline. I read that these formulations for taxanes were contributing to side effects profile of taxanes.
Wino115 wrote: Really value-added research JFM! I've had same question and I believe Spatrap mentioned this trial as a warning about getting too ahead of ourselves. I did very (very) basic research thinking that science has moved on and learned. That PDC v ADC primer that Scarlet put up a while back also mentioned some advances made on the linker and overall understanding of PDCs in the last few years.
Obviously I don't have the ability to get to this level but the few things I found were that they have also found some sort of "oils" or something that can also coat the PDC and it sort of dissolves or something over an hour, giving the PDC time to travel to it's homing spot. I have no idea if that is effective, real or what. But know seeing what you've uncovered, it sounds like the actual structure is more evolved and specifically designed based on what was learned in the Zop failure. Excellent and still worth a questino to Marsolais to understand this key issue better.