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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. It blocks viral entry into host cells while preserving normal immunologic function. The Company is also investigating an intramuscular method of administration of Trogarzo. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy.


TSX:TH - Post by User

Comment by qwerty22on Mar 09, 2021 12:17pm
95 Views
Post# 32753129

RE:RE:RE:RE:NASH partnership

RE:RE:RE:RE:NASH partnership

I think complete resolution of the regulatory position this year would be an important milestone for any partner. Grinspoon's heart fat trial should generate data this year, another interesting fat depot. Stanley's non-hiv, biopsied, NAFLD/NASH trial may readout next year. I'm hoping for an open-arm in the Ph3 to give some sort of interim data readout in the study population that would be informative (and derisking) ahead of the full data readout. There are some actual and potential milestones between now and approval.


jeffm34 wrote:

Push it further down the road?  If everything goes well you're looking at 3.5 years to see if the trial meets its end points. Then up to another year for FDA review and approval.  Yes NASH is a big market but it will also be a crowded market.  If there are oral treatments available, they will capture most of the market.  I don't think spending money and resources on the NASH program will provide the best return for TH.  

https://www.globenewswire.com/news-release/2021/01/14/2158320/0/en/Nonalcoholic-Steatohepatitis-Drug-Pipeline-Analysis-Review-2020.html


 

Wino115 wrote: From all you can see it looks like they want to push the NASH indication much further down the road before considering that.  I think any pharma would also want to see it pushed further down the road and happily pay up to get involved in something highly de-risked. If they prove it up, what they need in partnership isn't the science, but the distrubution globally since they own 100% worldwide rights. It's a good problem for them to have and figure out. There's just so many variables that can go either way over the next 12-18 months to provide clarity on things like that.  For instance, if oncology suceeds, they need to think about manufacturing and sales. Do you build, farm-out, partner-up, etc... Once again, great problem, but those will be very strategic decisions to make and move the flow diagram to another box. If you build on your specialty sales network with oncology, maybe you feel you can handle NASH in certain geographies.  I don't know, but all of that is highly dependent on the variables in front of them now.  One step at a time -- let's get efficacy, let's get hard data in humans (by the way, that was JFM who coined that term, not me.  I just like it).

Between cash and decent revenue forecasts they have (not outlandish either), they should be fine for next 2 years.  At that point, the Board will know what they need because you'll know if the convert is above the conversion point and you'll be in to your trials.  Now, you could also have some oncology revenue in 2022-2023 somewhere in there if things go well so that's a wildcard. So the issue will be if below the conversion price, you'll need to include that in your raise. If it's not included then you know the share is over $15, so dilution won't be huge to tack on $150mil or so which is probably all they need if oncology ramps to revenues. If it's below the conversion then it will be $50mil larger.  Issues for 2022-2023 to consider. The crazy wildcard woudl be that if they do get decent numbers on 2-4 cancer indications and we saw the Barclays guys pencilled in first year revenues for those refractory hard tumor types of around $250mil each and peak between $1.5-2bil each, with revenues doubling every year to get there, then you don't need a penny. In fact, time to start a nice dividend policy!  There's no way you could spend the free cash flow quickly enough. Problems to dream about......

 

 

FredTheVoice wrote: Jeffm34,

So Th bought back the rights for EGRIFTA,

And now, they will give some away again ?

Bad move in my opinion......

What if Oncology makes the stock rise so nicely in the next year, that the next financing, lets say, at 16$C, makes everyone very happy.....

FTV.

 




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