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Carvana Co CVNA

Carvana Co. is a holding company. The Company operates an e-commerce platform for buying and selling used cars. On the Company's platform, consumers can research and identify a vehicle, inspect it using its 360-degree vehicle imaging technology, obtain financing and warranty coverage, purchase the vehicle, and schedule delivery or pick-up, all from their desktop or mobile devices. It also provides automated vehicle valuations for buying vehicles from customers with or without a retail purchase, automated financing, vehicle service contracts (VSC), auto insurance, GAP waiver coverage, limited warranty, and other ancillary products. It offers pick-up and delivery options, including pick-up at its vending machines or hubs, and as soon as same day deliveries, depending on the market. The Company's in-house customer advocates are available to answer customer questions that arise throughout the process.


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Post by votrepaper18on Mar 16, 2021 10:27am
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WHAT ARE BARBITURATES?

Barbiturate is a group of sleep enhancer and tranquilizer drugs that are made from barbituric acid.

Chemical composition

As described above barbiturates are derived from barbituric acid. So they are available in the form of any salt of barbituric acid.

Mode of action

Barbiturates act by suppressing central nervous system. They relax the muscles of central nervous system by minimizing the activity of nerves. Our nervous system has a very important chemical that acts as neurotransmitter and it is called gamma amino butyric acid (GABA). The nerves of the central nervous system use this chemical neurotransmitter to be in touch with each other. The barbiturate suppresses this gamma amino butyric acid and in turn nerves are relaxed.

PENTOBARBITAL BARBITURATES

Pentobarbital is a short acting barbiturate. We can say it is a dangerous drug because when used in high doses, it leads to death.

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Pentobarbital is also available in the form of the salt of barbiturates. The process of synthesis of pentobarbital is very much like that of amobarbital. A little difference is that the alkylation of    α-ethylmalonic ester is carried out with 2-bromopentane in place of 1-bromo-3-methylbutane and produces pentobarbital.

Mechanism of action: Pentobarbital go through first-pass metabolism inside liver and most probably in small and large intestines.

Drug-Drug interaction: When pentobarbital is administered with other drugs such as benzodiazepines, ethanol, opioids, antihistamines, and any other sedative-hypnotic drugs, its action is enhanced. More sedative and hypnotic effect is observed.

Pharmacokinetics: Oral bioavailability of pentobarbital is 70-90% and rectal bioavailability is 90%. Its protein binding is 20-45% and elimination half-life is 15-48hours.

Uses of pentobarbital: 

  1. Pentobarbital is used for sedation and hypnosis.
  2. It is used in the treatment of sleeplessness.
  3. It is also used as anesthetic agent for treatments of animals.
  4. It is also used in Reye’s syndrome to minimize intracranial pressure.
  5. It is also used in euthanasia of animals as well as humans.
  6. This drug was used for criminals for putting them to death.
  7. Numbutal was the brand name of pentobarbital by Abbott Pharmaceuticals. It was available in yellow capsules in 50gm and 100gm. But this drug is discontinued from 1990 because of some suspicious deaths due to over dosage of Numbutal.
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CONCLUSION

Barbiturates are tranquilizing agents derived from barbituric acid. Pentobarbital is a short acting barbiturate. Its high dose can lead to death. In old times it was used for criminals. It is medically used as anesthetic agent in humans as well as animals. 

 

REFERENCES

 

https://en.wikipedia.org/wiki/Pentobarbital

 

https://www.medicinenet.com/barbiturates-oral/article.htm#what_are_barbiturates

 

https://www.google.com/search?q=what+are+barbiturates&oq=what+are+barbiturates&aqs=chrome.0.69i59j0l7.5035j0j15&sourceid=chrome&ie=UTF-8

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