RE:RE:RE:RE:RE:TH1902 effects on Progranulin The bottom chart on column 3 seems to suggest that the 3D tubes "vascular" tubes created are loaded with sortilin too. Perhaps another reason they are hopeful. It sure will be fascinating to see how this all works in patients. Let's hope we hear of miraculous things happening in Gettysburg again.
qwerty22 wrote: Sure delivering the chemo bomb might be all that is needed to finish off the cancer (let's hope so). But it may not. So identifying other MOAs might be extremely important. I'm jumping way ahead here but being able to say your drug also shuts down plasticity mechanisms in the cancer cell (I'm suggesting VM is just one mechanism of many), the sort of basic mechanisms the cell uses to spread and evade treatments is something that I think could contribute to the efficacy of the drug and certainly get partners salivating. I'm not saying the company has proved all this but it is potentially there and could turn out to be hugely valuable.
I like a targeted chemo bomb, I like a targeted chemo bomb with added extras even more.
jeffm34 wrote:
TH1902 doesn't have to competitively inhibit progranulin from binding to Sortilin. It kills the cells that have Sortilin leaving nothing for progranulin to bind to.
jfm1330 wrote: The competitive effect of TH1902 on sortilin receptors, versus progranulin is too short in my view to have any meaningful effect on cancer proliferation.
Wino115 wrote: I think you've stumbled upon one of the possible methods of action that both Spartrap and Qwerty are hoping is one of the 3 MOAs for TH1902. It may also be part of the disruption of vascular mimicry that they have seen in vitro. That is one of the more intriguing possibilities of the peptide and whole platform. If they can uncover that it does work beneficially in three different ways, it's not just a home run, it's a grand slam....or for our hockey-heads, a hat-trick!
jeffm34 wrote: If Th1902 can target and kill cancer cells that have Sortilin, it should also have positive effects on cancer progression by inhibiting Progranulin.
"Progranulin is involved in biological processes such as wound healing, inflammation and cancer progression. Progranulin and its receptor sortilin are known to be highly expressed in subgroups of breast cancer and are further associated with a clinically aggressive phenotype."