Antibe Therapeutics Inc(Pre-Merger) ATBPF

Healthcare

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.

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Antibe Therapeutics Inc(Pre-Merger) > Antibe's Stomach-Friendly NSAID Keeps Chugging Along

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Comment by Inthepezon Apr 05, 2021 9:18am

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RE:RE:RE:RE:Antibe's Stomach-Friendly NSAID Keeps Chugging Along

My explanation is directly taken from Wallace’s presentation in 2017: https://m.youtube.com/watch?v=w_3heP7ol0A

RjM2018 wrote: Inthepez - although Otena isn't a prodrug, your explanation of a prodrug isn't incorrect. See Definition below. Ex: Vyvanse is a prodrug of adderall...

Quote: "A pro-drug is a chemically modified structure of a known drug that is inactive until the active species is liberated by metabolism. ATB-346 is technically not a pro-drug since it breaks down to two active species."

Sources:

https://www.acsh.org/news/2020/03/01/huge-advance-pain-management-nsaid-without-gi-side-effects-clinic-14606

https://pubmed.ncbi.nlm.nih.gov/23563019/