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Theralase Technologies Inc. V.TLT

Alternate Symbol(s):  TLTFF

Theralase Technologies Inc. is a Canada-based clinical-stage pharmaceutical company. The Company is engaged in the research and development of light activated compounds and their associated drug formulations. The Company operates through two divisions: Anti-Cancer Therapy (ACT) and Cool Laser Therapy (CLT). The Anti-Cancer Therapy division develops patented, and patent pending drugs, called Photo Dynamic Compounds (PDCs) and activates them with patent pending laser technology to destroy specifically targeted cancers, bacteria and viruses. The CLT division is responsible for the Company’s medical laser business. The Cool Laser Therapy division designs, develops, manufactures and markets super-pulsed laser technology indicated for the healing of chronic knee pain. The technology has been used off-label for healing numerous nerve, muscle and joint conditions. The Company develops products both internally and using the assistance of specialist external resources.


TSXV:TLT - Post by User

Comment by Eoganachton Apr 11, 2021 4:17pm
295 Views
Post# 32974816

RE:Lumeda News

RE:Lumeda NewsI have it from an unimpeachable source that there are definite advantages to using TLD1433 over photofrin in IO-PDT for NSCLC, where the drug is placed right into the thoracic cavity. They are that the PS need not be given systemically and the patient would not be photosenstive after the treatment. No word yet from Roswell Park about what PS will be used in the second phase 1 trial, but we won't have long to wait,
 
It's good to remember that Roswell Park took the time and spent the money to conduct research into the possible use of TLD1433 in IO-PDT of NSCLC and that this research was only partially paid for by the National Cancer Institute at the National Institutes of Health. Theralase made no financial contribution to the research. Roswell Park's Sarah Chamberlain spoke about moving on to a small animal model after the sucess of the in vitro study, but so far no further information has been revealed about that.

TLD1433-Mediated Photodynamic Therapy with an Optical Surface Applicator in the Treatment of Lung Cancer Cells In Vitro

Eoganacht wrote: LUMEDA ANNOUNCES CLOSING OF $4.3M SERIES A FINANCING WITH CLINICAL STUDIES DUE TO COMMENCE IN 2021

Funding to advance product design and clinical testing as the company strives to improve outcomes for lung cancer patients

Rocky Hill, Connecticut – April 8, 2021 – Lumeda Inc., a medical technology company advancing Photodynamic Therapy (PDT) as an intraoperative adjuvant treatment for patients during lung cancer surgery, today announced the closing of its Series A financing. The round was led by Connecticut Innovations, with participation from Cycle Venture Partners, and brings the total amount raised to date to $5.3M. Both firms, along with angel investors, participated in the company’s Seed funding round in early 2020. The new capital will be used to further develop Lumeda’s breakthrough PDT system, which leverages artificial intelligence (AI) and proprietary software and hardware to enable controlled light dosimetry. Lumeda expects first-in-human clinical studies to commence in mid-2021.
 
“This new funding from our current investors shows their confidence in the Lumeda team and the opportunity to improve outcomes for lung cancer patients,” said Lumeda CEO, Sandy Zinke. “We are excited to begin clinical testing of the DigiLum™ system and plan to expand testing to other sites in the US, Europe, and Japan.”
 
Lumeda is advancing a medical device innovation, demonstrated by Roswell Park Comprehensive Cancer Center (“Roswell Park”), for applying PDT to treat Non-Small Cell Lung Cancer (NSCLC) and other lung malignancies. PDT is a two-stage cancer treatment that involves a photosensitizer drug that preferentially collects within cancer cells and then produces cell death upon light activation. PDT has been shown to significantly improve patient progression-free and overall survival when applied intraoperatively following lung cancer tumor surgical resection. Adoption of PDT to treat lung cancer has been limited due to its manual and time-consuming method of administration. With Lumeda’s new DigiLum™ system, thoracic surgeons will be able to use PDT in a shorter, simplified, intraoperative procedure with controlled light delivery and detailed data collection. Two clinical studies to evaluate safety and effectiveness are planned to begin at Roswell Park in 2021.
 
“Pleural malignancies of thoracic origin are difficult to treat and have a significant risk of recurrence,” said Dr. Sai Yendamuri, Chair of the Department of Thoracic Surgery at Roswell Park and Principal Investigator of the studies. “We are excited to evaluate Lumeda’s new light
dosimetry system for intraoperative PDT as a possible adjuvant tool to treat patients with lung cancer, which has the highest global incidence and death rate of all cancers.”
 
About Lumeda
Lumeda is a medical technology company advancing PDT to treat NSCLC and other thoracic malignancies. The company applies advanced photonics and proprietary artificial intelligence (AI) software to automate and digitize PDT light delivery to improve physician control, reduce procedure time and enable data capture for treatment planning. The multidisciplinary Lumeda team has decades of experience in the photonics industry, with expertise in systems engineering and commercialization of new technology. Lumeda is committed to pioneering the advancement and utility of PDT for improved patient outcomes. For more information, please visit lumedainc.com.


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