This study investigated sepsis patients' current status with continuous hemodiafiltration (CHDF) with or without polymyxin B hemoperfusion (PMX). We identified 17,367 adult sepsis patients treated with CHDF and PMX using the Japanese diagnosis procedure combination database (DPC) from April 2016 to March 2019. More than half of the patients in this category resulted in death in the hospital, which means that patients in this group were critically ill. Among the patients who received CHDF, the 28day survival rate of PMXtreated patients was significantly higher than that of nontreated patients, after adjusting the patient background by propensity score matching (69.5% vs. 65.4%, p<0.0001). Furthermore, the length of hospital stay and ICU stay was significantly shorter in PMXtreated patients than that of nontreated patients. These results suggest that PMX may provide benefits to patients with severe sepsis requiring CHDF.
https://onlinelibrary.wiley.com/doi/abs/10.1111/1744-9987.13655
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