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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy. Its portfolio includes Phase I clinical trial of sudocetaxel zendusortide (TH1902), a novel peptide-drug conjugate (PDC), in patients with advanced ovarian cancer.


TSX:TH - Post by User

Comment by SPCEO1on May 05, 2021 11:25am
94 Views
Post# 33132048

RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:So we go to the gate...

RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:So we go to the gate...I am with Scarlett on this. It is all about the messaging at this point. The range of possible final protocols is not that wide at this point and is not really a big deal. Investors are willing to make educated guesses about the future knowing they will be wrong on some of them while scientists like Qwerty just want the data before making any claims about a subject. It is simply a fact that investors and scientists look at these things differently and investors are willing to guess in order to gain an advantage whereas there is no such advantage to be had if you are a scientist by guessing. 

Complicating TH's messaging on NASH will likely be that they will not have secured the EMA's backing. So, we should expect TH to not be given full credit for NASH due to that weakness and the lack of data scientists insist upon in a pahse II. But we will have a FDA protocol and Paul certainly made it sound like that was pretty imminent. If they get the messaging around that correcct, even a big discount on the stock relative to its NASH peers could still propel it considerably higher.  

scarlet1967 wrote: I actually agree with you re the complexity of the protocol, lack of f2/f3 biopsies etc but despite all those shortcomings they did manage to convince FDA so their innovative approach and the totality of data was good enough to get the nod.
On the messaging my point is they should handle it much better to mitigate some of the skepticism about the somehow not conventional protocol.The way they handled it made the not optimal situation look even worse to the extent that the market doesn't ascribe almost any value to it. 

qwerty22 wrote:

The difference between you and me seems to be that you see the process as relately trouble free and it's just messaging and timing that screwed up the impact. For me things point to a complex and twisting process and the lack of clear messaging reflects that. It seems like you think THTX has been in control of the process all along where as I tend to think a lot of the decision making process has been reactive to what the regulators have allowed or not allowed.

My thinking is where the trial protocol finally lands is going to tell us something about the process and maybe where the lack of market response is coming from. Given my own scepticism a straightforward Ph3 where we wait 2+ years to see where the endpoints land is not the optimum situation. I think in that scenario you're asking the market to blindly invest in a very expensive trial when there is no data to inform it which ballpark the endpoints will land in because while the great data is directional it doesn't contain enough f2/f3 biopsy data to indicate what happens with the endpoints. My favoured outcome is for the company to offer the market a chance to invest in an interim data readout in the first instance, hopefully as part of a Ph3 that retains the huge benefits of being Ph3. If we get that not only does it solve outstanding issues but it'll point to what has made this process so tortured.

I'm totally onboard with me being wrong and over complicating things here.

So really I'm looking to get guidance from the finalized protocol, that's why the milestones are still the most important thing to me.

 

scarlet1967 wrote:

 

Let’s look at two scenarios, one the actual events and one a hypothetical version starting with the announcement of perusing HIV NASH program.
The first scenario the actual events:
The announced they will peruse the HIV NASH after a long wait (presumably because of changing the plan to go with General NASH), later on last year they eventually they announced they will go with General NASH based on the advices by the KOLs and they planned a meeting with agencies in few weeks, I believe they knew the market would be somehow skeptic so they brought in Dr. Grinspoon and Dr. Roomba to answer questions. They then decided not to announce the date of the submission of the protocol, the few weeks ended up being few months until early this year they announced both protocols were submitted and both got the letter may proceed from FDA but nothing about EMA. Soon after they closed the offering and the investor presentation was down for more than one week right after the closing so new to be investors couldn’t really make an educated assessment whether they should offload their position for a quick profit or they should stay put because they could make more profit due to potentials of the program.
The second hypothetical scenario:
They announced the HIV NASH and instead of waiting a long time as soon as they planned to explore the idea to go with NASH they would inform the market that they potentially will change their plan and are in the process to validate their decision by consulting the KOLs, why? Because the long wait between the two news killed all the excitement so they could keep the story relevant by communicating all the stages of their decision making process.
They knew the market will be skeptic so they should produce that life science report before the general NASH announcement to mitigate some of the skepticism.
They should also upgrade the website in advance to maximize the effect of the good PR. Although not conventional they should inform the market when the protocol was submitted why? Because surly it would not affect the agency’s response but by not announcing the submission they created more uncertainty about the legitimacy of the protocol, they effectively send a message that they are not confident about the protocol fearing rejection. They would also communicate more clearly as where they stand with the EMA re the NASH.
After the good PR they would wait for the information to get digested by the market and attend few conferences explaining the protocol to both retail and institutional investors, the net result would be an appreciation of the valuation and potentially much better deal as their science and its risks/rewards had been explained and understood by the market so instead of almost not getting ascribed any value to the program some value would be baked in to the SP.
In my view they didn’t handle the information flows correctly, it wasn’t lack of marketing but really bad marketing, many wrong decisions were made leading to the current low demand/valuation. They seem to agree with part or all of this assessment as they will RE-engineer the company’s marketing. My concern is after a number of bad moves from this company how much faith one can have in their abilities to RE-engineer? Of course the board is not involved with day to day activities but we are talking about big strategic decisions which a proactive board ideally should be involved with.
 

 




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