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Antibe Therapeutics Inc(Pre-Merger) ATBPF

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.


GREY:ATBPF - Post by User

Comment by WalkOverTheStrton May 12, 2021 2:52pm
156 Views
Post# 33184296

RE:RE:Catalyst

RE:RE:CatalystAgree with majority esp if Dan and team GIA but not:

"I don't think that new pipeline success would be much of a catalyst for institutions to risk capital either because the market/institutions have heard the H2S story for many, many years.". 

I've followed RNAI for years which has been in the works since the early 2000's and just like HS2 was on the back burner until recently (last 2-3 years see ALNY, ARWR, Dicerna, etc.). It wasn't until mutliple drugs in human trials proceeded successfully esp with the trail blazer ALNY that the value of those companies increased dramatically.

I'll state this until my fingers fall off -  there is no platform without multiple successful human trials. We can debate why Dan and team decided to not run multiple human drugs (capital, focus, delays, etc.) but BP as you pointed out is cautious and prudent. One drug is PH3 with no other human trials to point to is a weakness if mgmt is trying to sell the entire company (which I believe is the final outcome).  i'd also counter that Otel probability of success is higher than 60% based on the entensive studies performed on NSAIDS as well as the PH2 A and B studies...

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