RE:RE:RE:RE:Moving on I posted this earlier the article goes on also suggesting combination therapies as another approach to bypass the MDR.
This article published yesterday emphasized the urgent need for a targeted drug therapy such as PDC for among others metastatic breast cancer due to multidrug resistance, Thus far a combination of anticancer drugs has been used as standard chemotherapy treatment although this approach has been showing success for early stages of cancers eventually the chemotherapeutic agents flow out of the cancer cells and patient develop multi drug resistance to common anti-cancer drugs. Also chemotherapy mostly involves use of hydrophobic drugs that can be rapidly cleared from the tumor site due to their small molecular weight. This can result in lower circulation half-life and sub-therapeutic concentrations at the tumor site. To remedy the problem to certain extent a targeted anticancer drug delivery into cancer cells could result in higher dosage of the agent thus mitigate the multidrug resistance issue.