RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:RE:The other two clinics Isn't the hair falling out because taxol, lose in your system, attacks all fast growing cells of which hair is one? If the docetaxol is directed primarily into the tumor cell and stays there, might it lessen this side effect quite a bit? Not that it's important, but I'm thinking it could be a signal of the benefit of sortilin as a target and it's internalization function.
juniper88 wrote: I would think that if the Peptide cannot hone in to a sortilin receptor then eventually it would break down and the payload is release into the blood stream, similar to getting just a Taxol IV. My wife has had 11 cycles of taxol, which is very toxic. Taxol IV requires premeds, for example IV Benadryl because allergic reactions to Taxol can occur. Also, the IV is put in on a graduated basis. So, they start very slow and monitor the patient very closely. If nothing happens after 15 minutes the nurse increase the IV speed until eventually full speed is reached.
From my understanding, in the TH1902 trial there are no premeds and the IV is done at full speed. At a higher dose, if the peptide does not work I imagine you would find out rather quickly.
Also, Taxol is one of the Chemos that causes your hair to fall out (not all chemos do, my wife current treatment Carboplatin with Caelyx has allowed her to keep all her hair.) So, even the patient should be able to notice if TH1902 is working with out any bloodwork. The hair start falling between the 2nd and 3rd week after the treatment.