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Antibe Therapeutics Inc(Pre-Merger) ATBPF

Antibe Therapeutics Inc. is a clinical-stage biotechnology company. The Company is leveraging its hydrogen sulfide (H2S) platform to develop therapies to target inflammation arising from a range of medical conditions. The Company’s pipeline includes assets that seek to overcome the gastrointestinal ulcers and bleeding associated with nonsteroidal anti-inflammatory drugs (NSAIDs). Its lead drug, otenaproxesul, is in clinical development as an alternative to opioids and NSAIDs for acute pain. Its second pipeline drug, ATB-352, is being developed for a specialized pain indication. The Company also focuses on inflammatory bowel disease (IBD). Otenaproxesul combines a moiety that releases hydrogen sulfide with naproxen, a non-steroidal, anti-inflammatory drug. ATB-352 is an H2S-releasing derivative of ketoprofen, a potent NSAID commonly prescribed for acute pain. Its IBD candidates are being designed to maintain the efficacy, safety, and pharmacokinetic properties of ATB-429.


GREY:ATBPF - Post by User

Comment by WalkOverTheStrton May 20, 2021 11:03pm
131 Views
Post# 33246118

RE:From Toxicity to Therapy:Effects of Hydrogen Sulfide

RE:From Toxicity to Therapy:Effects of Hydrogen Sulfidegreat  link, makes the case for Antibe more clear. Hang in there longs, juice will be worth the squeeze.

"Tissue repair and wound healing result from the numerous well-described molecular and cellular effects of H2S, including activation of sulfur-containing amino acid metabolism, inhibition of oxidative stress and inflammation, and stimulation of angiogenesis (19465274). Indeed, H2S has been characterized as a free radical scavenger, neutralizing reactive oxygen species, while concurrently enhancing the efficacy of endogenous antioxidant molecules (65). In turn, these effects contribute to resistance to oxidative stress and protect endothelial function, sustain blood flow, and preserve organ perfusion. Recent findings also demonstrate that a novel H2S-releasing derivative linked to ketoprofen generates significantly greater analgesic benefits versus ketoprofen alone (11)."
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