SPCEO1 wrote: I do not know what is going on with the phase I trial but here are some observations which may or may not be relevant:
1.) This is the first cancer trial in the history of TH. It would not be surprising if they did not get everything exactly perfect when we look back at decisions they made at a later date.
2.) This is trailblazing work they are doing in cancer research. There are no doubt some blind corners they are going to have to turn. Accordingly, we should expect some bumps inthe road as the trial proceeds.
3.) It seemed to me the time period between Mr. Snyder's first and second dose was longerr than what I thought was likely. So, given his evident poor health going into the trial, some issue may have arisen that slowed the dosing regimen for him. And since he sadly passed away, it seems reasonable to assume that he may have been pulled from the trial before he ever recieved a third dose due to his deteriorating health situation. Just guessing, but it is possible this has delayed the phase I dose progression efforts some.
4.)
MD Anderson has been recruiting for a while now. I have to believe they have been able to find a number of potential patients for the phase I and things aree progressing. So, maybe things are pretty much on track with it.
5.) Hopefully, TH will give us an update on the phase I on 6/21 after which we will know exactly where things stand and if time lines have been pushed back some or if everything is still on track. From the language they have used in their press release, it is not clear to me they will be giving us a phase I update, but hopefully they will.
I don't think we should assume that the phase I trial will go completely smoothly. We should anticipate some bumps in the road but, even so, that should not undermine the ability to reach a successful conclusion.