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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy. Its portfolio includes Phase I clinical trial of sudocetaxel zendusortide (TH1902), a novel peptide-drug conjugate (PDC), in patients with advanced ovarian cancer.


TSX:TH - Post by User

Comment by Wino115on Jun 16, 2021 11:32am
102 Views
Post# 33395305

RE:RE:RE:Part of the challenge for TH

RE:RE:RE:Part of the challenge for THThose are exactly the right questions to ask and with their investor strategy, they must assume they  are near the bottom of investor attention, as you say.  All of this is far easier with clinical success which brings into focus the future of the pipeline. We and these new investors who bought in see reason to be hopeful, but the rest of the market won't notice anything unless the clinical data is highly supportive.  

If we can get to that point, it will be very interesting to see analysts stumbling over each other to understand what's happening in their trials (we can still hope!).  If the data goes the right way, it will be one of those cases where anyone even loosely following it will happily miss the first move, however strong that will be, and get on once there's a lot less risk, but still a nice reward. We're already up 100% from last years bottom and really only 4 investors got half of that. It's quite amazing how much money many investors are happy to leave on the table to wait for confirmation. 

One way we used to think about it was that you could actually "earn" the same dollar amount for your investors because at this stage of THTX where there's perceived clinical risk, you wouldn't invest as much, so your $ gains would be, say, X$ if you get it all right.  The alternative is you wait for confirmation, invest 4 times as much for the last chunk of gains and you still end up with X$ as profits and didn't have to take the clinical risk.  It's hard to argue with that approach provided the volume is there later. 

I just want to get to the data stage so we have the foundation to support this capital market strategy fully. 

qwerty22 wrote:

It's a great article but in a way there is an assumption in it of building from a neutral place to success. But that doesn't quite fit with THTX because they've pretty much been on the typical biotech rollercoaster ride and are at the bottom. So it's more than just building relevancy, there's restoring reputation having burnt all their bridges. I think my mistake  was to think they could do that more quickly with NASH but that's dragged on and been less than straightforward.

2021 looks like the moment to finally start rebuilding, the ongoing lack of interest is frustrating and perplexing though.

I like the article, I like the idea of constantly working at making yourself relevant but I think that work only pays off when it syncs with other aspects of the business.

Where they just not doing this relevancy work in 2019/2020? Where they doing it but doing it badly? Where they doing it but pushing against a locked door? With the 2021 milestones will the doors open?

 

 

 

scarlet1967 wrote:

 

 

I believe all the below from that article applies to the whole market, stock markets is mostly a closed system so the the same capital goes around between all listed companies, meaning there is a significant competition for those funds whether the source of money is the retail segment or institutions. Those who managed to master the “relevancy challenge” by doing all this article is referencing to and more will be the ultimate winners. Specifically for R&D companies it’s all about selling their programs.

 

“There are two ways for a fund to make room for new “core” positions. They can sell out of a position, believing their capital is better deployed elsewhere (due to either valuation levels or a loss of conviction on the biotech’s prospects). 

 

So all these trends highlight the “relevancy challenge” in the biotech equity capital markets today: in an ever-expanding world of names, where the “supply” of possible core positions is outstripping “demand” for additional core positions, how does a biotech become or maintain relevance to the best long-term investors?

The obvious answer is to have an unusually compelling story to tell with great data revealing huge potential for transformative impact on patients. Much easier to say then to truly demonstrate, and “compelling” for an early stage story is often in the eye of the beholder.

 

This includes detailed investor outreach plans built around the company’s key milestone/data releases, as well as medical and scientific meetings, publication strategies, and investor conferences.”



 

SPCEO1 wrote: Interesting article. Here is the concluding paragraph:

The bottom line is that achieving and maintaining relevance with the top buyside funds in an ever-expanding universe of investable opportunities only comes through hard work and planning, plus a healthy dose of good fortune in R&D. This buyside relevancy is critical to getting the attention required to access funding at a reasonable cost of capital – which is an existential requirement for success in loss-making R&D-stage biotech over the long term.

https://lifescivc.com/2021/06/biotechs-relevancy-challenge-in-an-expanding-universe/
 

 

 

I believe all the below from that article applies to the whole market, stock markets is mostly a closed system so the the same capital goes around between all listed companies, meaning there is a significant competition for those funds whether the source of money is the retail segment or institutions. Those who managed to master the “relevancy challenge” by doing all this article is referencing to and more will be the ultimate winners. Specifically for R&D companies it’s all about selling their programs.

 

“There are two ways for a fund to make room for new “core” positions. They can sell out of a position, believing their capital is better deployed elsewhere (due to either valuation levels or a loss of conviction on the biotech’s prospects). 

 

So all these trends highlight the “relevancy challenge” in the biotech equity capital markets today: in an ever-expanding world of names, where the “supply” of possible core positions is outstripping “demand” for additional core positions, how does a biotech become or maintain relevance to the best long-term investors?

The obvious answer is to have an unusually compelling story to tell with great data revealing huge potential for transformative impact on patients. Much easier to say then to truly demonstrate, and “compelling” for an early stage story is often in the eye of the beholder.

 

This includes detailed investor outreach plans built around the company’s key milestone/data releases, as well as medical and scientific meetings, publication strategies, and investor conferences.”





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