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ProMIS Neurosciences Inc PMN

ProMIS Neurosciences Inc. is a clinical-stage biotechnology company. It is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). Its proprietary target discovery engine applies a thermodynamic, computational discovery platform-ProMIS and Collective Coordinates-to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product candidates are PMN310, PMN267, and PMN442. The PMN310 is a monoclonal antibody designed to treat AD by selectively targeting toxic, misfolded oligomers of amyloid-beta. PMN267 product candidate targeting ALS. PMN442 is a drug candidate being developed for MSA designed to selectively target and protect against pathogenic a-syn species.


NDAQ:PMN - Post by User

Comment by Speyeder999on Jun 25, 2021 1:04pm
253 Views
Post# 33451035

RE:Only 1 analyst

RE:Only 1 analyst It must be complete speculation at this point to put a price on  the company"s worth if you aren't in "the know". I think everone knows at this point (or hopes) that the SP is undervaled, but by how much?, is anyone's guess.

When I re-read an excerpt from the first quarter results that stuck with me (see below) you'd think that PROMIS is sitting on THE HOLY GRAIL  of cures for pathology as a whole, and maybe they do, who knows, but if so,  why haven't they partnered with anyone or clinched the $$$ (besides the Boston group)  to move forward?


"In addition, in collaboration with Dr. David Wishart of the University of Alberta, we have enhanced and extended our unique technology platform. ProMIS Neurosciences has a unique antibody design capability, which not even the largest pharmaceutical companies have to the best of our knowledge based on ongoing discussions with them. We are able rapidly and cost effectively to design and create antibodies or therapeutic vaccines that only target toxic, mis-folded versions of proteins that otherwise play a normal healthy role. This capability has given ProMIS a growing portfolio of potential “best in class” monoclonal antibodies (or corresponding therapeutic vaccines), including our lead program PMN310, targeting toxic oligomers of amyloid in Alzheimer’s. In the Alzheimer’s field, positive results or regulatory steps were announced by Lilly, Cassava, and Biogen, all of which support the science suggesting PMN310 may be “best in class"

If we assume for a moment that PROMI'S science is valid (which we all hope) then the only conclusion I can come to is that the company is asking way to much(SSS) or the conditions simply do not suit the big pharmas. So, the real question here  is ''HOW MUCH IS THE TOO MUCH?'' and on what terms?




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