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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy. Its portfolio includes Phase I clinical trial of sudocetaxel zendusortide (TH1902), a novel peptide-drug conjugate (PDC), in patients with advanced ovarian cancer.


TSX:TH - Post by User

Post by jfm1330on Jun 27, 2021 12:29pm
260 Views
Post# 33457562

Clear proof of concept is the key

Clear proof of concept is the keyIf they can come up with clear efficacy results, the stock price will rise significantly. By how much? It is hard to tell with this market, but if the skepticism barrier is broken, then the pendulum could swing totally to the positive side. If that happen, this will mean access to a lot of money to drive this program aggressively.

Again, we are not talking about one molecule aiming at only one type of cancer. A clear proof of concept would open the door to a very wide array of possibilities, and one of the great thing is that it is a simple technology that can be quickly applied to all kinds of anti-cancer agents. The peptide is easy to make and they have it under GMP grade, approved drugs already exist, they don't need to make them, they just need to buy GMP grade API of these molecules. Then the only new process for each of them will be to link the anti-cancer agent to the peptide. Marsolais said in the last presentation that they can attach any drug to TH19P01, and I know that radioisotopes would be easy to attach too.

So we are not talking about very complex technology here, like CAR T-cell, or personalized stuff like that. What I am trying to explain is that the manufacturing side would be quick to develop for any new combination of TH19P01 + linker + cytotoxic agent. The three pieces can be manufactured seperatly under GMP and everything. Then, for every new project it would only be the final assembly of the three parts that would need to be validated. So it would be a very rapid process by normal pharmaceutical standards. So money would allow a lot of things that are not very complex.
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