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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy. Its portfolio includes Phase I clinical trial of sudocetaxel zendusortide (TH1902), a novel peptide-drug conjugate (PDC), in patients with advanced ovarian cancer.


TSX:TH - Post by User

Comment by Wino115on Jun 29, 2021 12:22pm
142 Views
Post# 33466320

RE:Interesting conversation

RE:Interesting conversation

Indeed this is interesting and maybe we should expect that.  We know that one PDC failed because it wasn't strong enough to deal with the acidic tumor environment (JFM has stated the design of TH19P01 is different and more robust), and that only 2 are commercialized.  As many have said here, this is a new approach (PDC) and Sortilin is a ground-breaking new tumor target never tested outside of labs to our knowledge.  Until they can publish trial data and get it into conferences, publications, or get PR from it, it will likely not be widely known yet even in the profession.  


Bucknelly21 wrote: So unlike some here I am not scientifically inclined, however I do understand what we have and how it works. Last night I was at a charity event for an athlete in Seattle. His charity is big into cancer research at Seattle children's hospital. They had two of the main doctors here. They have been treating children with T cell therapy and having some success. I felt like it was a good opportunity to ask about their thoughts on pdc treatment ect. Needles to say they were convinced that targeted therapy was the future of oncology. They both didn't know much about pdc so I began to explain the platform to them and how it worked ect. They both thought it was extremely impressive to get fast track pre clinical. They were both adamant that at the point we are even if no data is reported on efficacy that have super low toxicity outside the tumer would be enough to move the needle and start getting lots of attention from different people/pharma. He stated that the "big guys" seem to be more interested in buying potential new technologies at a discount in the beginning stages of the research rather than develop it on their own. He said they are looking for as many shots on goal for as cheap as possible rather than trying to r&d it on their own. He was convinced based on what I showed him if we get through this first part and show some even a little anti tumor activity that we will start to see people making plays at thtx based on what he's seen in the last 10 years. Anyway thought I would share I thought it was interesting how these two top guys at Seattle children's knew very little about pdc tech. Which says to me that's where the muted response to some of our oncology stuff is coming from. Thtx has a real opportunity to be the first to make pdc treatment mainstream 

 

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