RE:RE:RE:Dose escalationReaching a high MTD is important because it would be a good predictor of efficacy, but it would be more than that. It would point to the demonstration of the proof of concept, which is the ability of TH19P01 to concentrate a cytotoxic drug in the cancer cells. If you can establish that proof, it opens the doors to a wide array of othe PDC combination with other cytotoxic agents. So the key here is not just proving that concentrating docetaxel in advanced cancers can be efficacious, the othe key is to prove the ability of TH19P01 to concetrate a drug in cancer cells. If it works with docetaxel, it is very likely to work with many other drug. So efficacy proof is good for TH1902, but proof of concept is good because it valdates the whole platform.