RE:RE:RE:Dose escalation ... or if it's not bypassing resistance so chemo resistant cells are pumping the drug out as fast as Sortilin is moving it in.
.... or if the docetaxel is not efficiently being released from the PDC inside the cell so it doesn't become active.
.... or if the PDC is not able to get to the cells in the first place, that's to say it doesn't efficiently penetrate the tumour.
All the things they highlight about the drug need to work to some extent to get the final effect. Some of these things have been better "derisked" in the preclinical work than others.
jfm1330 wrote: The only explaination would be that docetaxel is not efficacious against certain type of cancers, but it is hard to imagine it would not work against every cancers. That's why the scientific logic leads to think that if the MTD is high, efficacy should be there.
stockman75 wrote:
Jfm thanks for this great information/analysis. From a scientific perspective how would you explain a scenario where they have such large MTD dosage and NOT have very good efficacy (for sortllin expressing cancers)? Thanks