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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy. Its portfolio includes Phase I clinical trial of sudocetaxel zendusortide (TH1902), a novel peptide-drug conjugate (PDC), in patients with advanced ovarian cancer.


TSX:TH - Post by User

Post by Wino115on Jul 30, 2021 7:09am
272 Views
Post# 33630950

Gilead oncology

Gilead oncology

Gilead reported light earnings as HIV drugs didn't grow and Remdesivir shrank.  Recall they bought Immunomedics for the breast cancer ADC Trodelvy.  There ongoing breast cancer trial is called TROPICS-2 and it's an ADC targeting Trop-2 but using that SN-38 toxin. Here's the Barclays comment mentioning even if statistically significant they don't see the data leading to clinical use. So it brings in to question Gileads strategy to grow oncology.  

"While we think TROPICS-02 will likely reach a statistically significant result, we're less sure of clinical significance and near-term SERD read-outs could complicate the HR+ metastatic breast commercial opportunity. We acknowledge investors may view the downside as limited here with the stock trading <10x on 2021E EPS, however, we think this misses the potential negative implications and perception surrounding Gilead's oncology strategy if TROPICS-02 data doesn't result in an approval, particularly with minimal EPS growth on the horizon over the mid-term."

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