RE:Kaplan's posterI guess I shouldn't be surprised that no one here had a constructive comment, it's complicated if not esoteric.
If Gene's update can be believed then this is novel, i.e. it's not the same as propagation by templating the whole misfolded protein. So does this mean the epitope itself can spread the disease, or would it be just minor contributor?
templating backgrounder: https://www.hindawi.com/journals/ijcb/2013/975832/
Is Gene understating that Promis's mabs are hitting bullseyes that the competition doesn't even have the field glasses to see? Or is this just a refinement of the templating explanation?
It's too complicated for me even when Cashman/Plotkin et al. try to explain it.
https://www.frontiersin.org/articles/10.3389/fnmol.2019.00262/full