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ProMIS Neurosciences Inc PMN

ProMIS Neurosciences Inc. is a development stage biotechnology company. The Company is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA), an alpha-synucleinopathy. Its proprietary target discovery engine applies a thermodynamic, computational discovery platform - ProMIS and Collective Coordinates - to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product portfolio includes PMN310 / Amyloid-beta, PMN267 / TDP-43, and PMN442 / Alpha-synuclein. The Company plans to investigate additional synucleinopathies, including Parkinson's disease (PD) and dementia with Lewy bodies (DLB). Its wholly owned subsidiary is ProMIS Neurosciences (US) Inc.


NDAQ:PMN - Post by User

Comment by retiredcopon Aug 06, 2021 5:26pm
76 Views
Post# 33667277

RE:RE:RE:Dr Cashman was onto the problem decade ago

RE:RE:RE:Dr Cashman was onto the problem decade ago In the early stages of this company,  Dr Cashman was one of the few researchers that was implicating protiens as the basis for many diseases not just prion. he maintained that view even though most other scientists were saying that he was completely off course in his thinking. I think that sometime IN the mid 2000s he made presentations at a  international conference and at that time some type of committee associated with AD or  Parkinson's specifically acknowledged his work and confirmed that his line of thinking and his approach to treatments for these diseases as it related to proteins was in fact correct ...this created a interest by other researchers to go that route,  but this is where PMN suddenly was ahead of everyone because his science was already in place . We started to see the possibilities of our science being used in diseases like cancer. About the same time we showed proof of concept with ovarian cancer,,, a BC cancer group conducted  studies with our treatment and it showed that the drug was only attaching itself to the ovarian cancer cells and not healthy cells. The project died as Amorfix just about went under with lack of funds. Many of us have been discussing the need to resurrect this project with a partner as it had incredible potential. WHEN PMN was created , the company decided to focus on the science we had that had the mostpotnetial value and was closest to coming to fruition ... It was decided that AD was the closest to completion and all other previous projects would be on hold. THERE WAS AN EXECPTION MADE as Dr Cashmans research into ALS would continue as this was the closest and most personal disease he was dealing with and he has made it a personal goal to solve that disease before his time runs out.   
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