RE:RE:Cost of Lutathera in CanadaIt's too early for them to talk about that. They need efficacy data first. But if TH1902 shows good efficacy, then it will be the time to push that forward.
Wino115 wrote: This is a key point for their potential profitability. While PL and Marsolais always state the characteristics around TH1902 may be a new paradigm for the way you treat cancer, PL and Dubuc need to start highlighting that this also, by definition, means it could lead to a new financial model paradigm as a result. The characteristic of possibly longer patient treatment periods and more frequent dosing supports a far more robust commercial model versus standard cancer company treatments. This point needs to be incorporated into their presentation if this supposition is true, which it seems preclinical would support.
jfm1330 wrote: I found a pricing reference for Lutathera in Canada. It also includes the pricing for Sandostatin LAR, a peptide drug, and also the cost of chemotherapy drugs for neuroendocrine cancers. The cost of Lutathera is 140,000$ CAN for four cycles, so 35,000$ per dose. Initiation of treatment is four cycles every two months, maybe more if they see good tumor regression. If it's only stable disease, they will treat again when they will see cancer progression again.
The cost of Sandostatin LAR (Octreotide LAR 60 mg) is 4000$ CAN per dose, with a dose every four weeks, so 52,000$ per year only for a long acting release formulation of the peptide. So it gives a good idea of the pricing TH1902 and other PDCs derived from TH19P01 could achieve. I did not find the pricing in the US, but it is surely higher by a good margin.
So imagine the pricing for a PDC like TH1902 with treatment cycles of three weeks, instead of two months. You could end up maybe with 10 to 20 cycles of treatment given the expected wider therapeutic window. Obviously, it needs to be efficaciuous.
https://www.cadth.ca/sites/default/files/pcodr/Reviews2019/10142LutetiumLu177dotatateGEP-NET_inEGR_NOREDACT-ABBREV_Post_31May2019_final.pdf