RE:RE:Exactly How Does TLD1433 Kill Cancer Cells?NorCalTommy ... Having been invested in TLT for so long and having vomited on TLT management in all your posts, it's surprizing that you don't even know the answer to your basic question!
A new molecule has to go through all the testing steps, as this is ... a new molecule. Science measures. Doesn't make assumptions.
You'd be the first to blame regulatory bodies for having skipped some steps based on your reasoning or on wrong assumptions if you ended up having some issues that had not been covered properly "just because we thought it would be the same as ...".
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NorCalTommy - (8/9/2021 11:55:35 AM) RE:Exactly How Does TLD1433 Kill Cancer Cells? Kudos to Sherri for the NSF grant!
Question:
If better, more effective photodrugs than TLD 1433 are discovered, would TLT need to start back at square 1 with phase 1 trials OR would the new more effective drugs be inserted in place of TLD 1433 in the 'Process'..... i would think there would need to be some testing of the 'new improved photodrug' but to what level/extent? Hopefully not a multi-year process of testing the new PS every time a new rev comes out??
"This insight regarding the potential photobiological mechanism(s) of TLD1433 and related PSs could lead to the development of Ru(II) photodrugs with even better properties than TLD1433".
Thanks! NCT