RE:RE:Today’s NR"My only hope is that they are working with patients with trashed immune systems...lets recruit some patients who never had radiation or chemo..."
Exactly !
If you read through the trial data, and I cannot recall the exact terminology that they use, but the majority of these patients have already gone through other treatments of chemo, radiation, steroids, etc. and they have failed with limited survival expectations. Their imune system are heavily burnt out. And even at that, PELA has extended thier lifes well beyond what was anticipated. These are lliterally people with little hope having their lives extended by PELA in combination with other treatments.
So YES, imagine if a young mother in early BC stages with a generally healthy imune system is given PELA and TECENTRIQ. My guess and hope would be there would be no need for chemo, radiation or steroids or worse surgical removal. PELA and TECENTRIQ would do their job and teminate the cancer. Wow!
That will be a day to celebrate and is worth a lot of money.
But unfortunately the FDA will not run these trials on early stage BC so we have to get through these trials first.
So in AWARE-1 we have seen 72% of evaluated patients (n=18) saw an increase in CelTIL, the study's primary endpoint that is associated with favorable clinical outcomes.
- The maximum percentage increase in CelTIL (~300%) was achieved in a cohort 2 patient receiving pelareorep in combination with checkpoint blockade therapy.
- On average, there was a 105-fold increase in TME PD-L1 expression (n=13) from baseline (pre-pelareorep administration) to surgery (21-days post-administration).
- Pelareorep strongly increases CelTIL score, the primary endpoint and a measure of tumor cellularity and inflammation associated with favorable clinical outcomes
- Pelareorep increased tumor PD-L1 expression 105-fold, thereby making the tumors more amenable to immuno-checkpoint inhibitor treatment
All with taxed/burnt out imune systems.
I am hoping the final data from the AWARE-1 is much more definitive in it's language than 'favourable' and 'amenable' with something the market can sink their teeth into.
Hey, I was just reading this report, https://leedejonesgable.com/wp-content/uploads/ONC_2021_08_09.pdf There are some interesting notes in there.
Look at the comparable companies and their SP.
Look at the forecasted revenue on page 2... But I think that is irrelevant cause IMHO I believe they will be bought out so big pharma can run the Phase III trial their own way. See my other posts.
Look at the list of all the EXPERIMENTAL BC therapies that PELA might enhance the results of on page 6. (Speculation.. YES)
Look at the list of APPROVED BC drug therapies that PELA might enhance the results of on page 7 & 8. (Speculation.. YES)
A bit of speculation there, but very interesting to see and contemplate.
Look at page 4 of the anticipated milestones in H2 2021, so in the next few months before year end. H2 2021 will be very interesting and IMHO we will see the historical annual SP climb.
What ?
Yes, with all this news, I expect the price to climb back up to $6.50 again or higher. Whether it gets to $8.50 as this target price suggest, I don't know. I need it over $9.03 CDN for my warrants to be in the money, as they expire June 1, 2022. Unless they get extended or bought out.
But with that said, every year we see the same thing. We head into fall with all these NRs forecasted. July, Aug and Sept the SP price historically falls off. Then with the expectation of H2 news the SP climbs back up, but lately even higher than the previous year. ONC's over all chart has been on a general climb (excluding the spikes and the dip we are currently in) since March 2019. I expect ONC will exceed last year's SP high through this NR cycle.
How long it stays there is anyone's guess.
But the continuation of the same style of NRs will cause the stock price to fall back again in 2022.
So, if any one likes to play the curves, IMHO now is the time to buy in this low with this on-set of upcoming NRs and sell in Dec 2021 or early January 2022, maybe even hold into Feb 2022. But you got to watch it. I don't like saying this, as everyone will likely slam me for this, but IMHO it's almost a guaranteed double bagger or more maybe (at this price) based solely on ONC trading history. That IS the historical pattern of ONC.
Do your own research. We see it every year again and again.
That curve is what a lot of investors including myself have been playing over the years. YES, I hold a fist full premenantly and will hold them to the end, but have some shares that I play the curve with as well. Increasing my hold every year on this repetative curve cycle buying in the later summer low and seling into the high around year end,
Or
IMHO I am still looking at ROCHE to possibly buy out after the release of the final AWARE-1 results. See my other post. Maybe ROCHE will just buy my shares from me... :) I wish !!!
Have a Great Day !