GREY:ATBPF - Post by User
Post by
WalkOverTheStrton Aug 13, 2021 5:22pm
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Post# 33704854
A PH2 recommendation
A PH2 recommendationAdvice to mgmt: Run the trial with 50mg and 75mg through four weeks, not two like the previous PH2.
Why?....
1) WOMAC scores - Allows more time for HS2 to work - Joe during the Canaccord meeting at minute 10:30 points out that Otnenal WOMAC scores which are inline with other NSAIDS studies but Otenal was at two weeks vs the others at 12 weeks...Alluding to fact pain reduction could / likely would increase over time making the case for 75mg. Heck also test 50mg...
If this isnt being considered by Joe than someone close to him nudge him...
2) Better to fail in a PH2 and highlight a safety issue on a longer term dose than have even more sunk costs for a PH3. If liver and other functions are good at 75mg and / or 50mg AND WOMAC meets the bar then they know PH3 should also be fine.
Slide 16 - https://secureservercdn.net/72.167.241.46/ln9.cea.myftpupload.com/wp-content/uploads/2021/07/Antibe-Corporate-Presentation-July-2021.pdf