GREY:ATBPF - Post by User
Comment by
Rawrasauruson Aug 18, 2021 2:14pm
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Post# 33724487
RE:Not a Scientist but...
RE:Not a Scientist but... Long term, I would be incredibly surprised if this kills the drug. It's just not clinically significant. Even at 5x increase in enzymes, that's still lower than Tylenol and even Naproxen. Naproxen alone can lead to elevations in adverse events around 500+ whereas 5x only puts us in the 250 range.
Best guesses are still NAFLD or genetic variability of the patient populations rather than something inherent to the drug. It appears we can go lower though, so even if it is the drug that is inhibiting a certain pathway for clearance, that just changes our dosing schedule to achieve stable serum levels. Remember, the goal here is long term oa 1x daily treatment. If we can prove gi/lte safety and pain relief over the long term, we are golden even if the drug takes a week or two to reach serum stability.