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Oncolytics Biotech Inc T.ONC

Alternate Symbol(s):  ONCY

Healthcare Biotechnology
Oncolytics Biotech Inc. is a clinical-stage biotechnology company. The Company is focused on developing pelareorep, an intravenously delivered immunotherapeutic agent that activates the innate and adaptive immune systems and weakens tumor defense mechanisms. This compound induces anti-cancer immune responses and promotes an inflamed tumor phenotype turning cold tumors hot through innate and adaptive immune responses to treat a variety of cancers. This improves the ability of the immune system to fight cancer, making tumors more susceptible to a broad range of oncology treatments. The Company’s primary focus is to advance its programs in hormone receptor-positive / human epidermal growth factor 2- negative (HR+/HER2-) metastatic breast cancer and advanced/metastatic pancreatic ductal adenocarcinoma to registration-enabling clinical studies. In addition, it is exploring opportunities for registrational programs in other gastrointestinal cancers through its GOBLET platform study.


TSX:ONC - Post by User

Oncolytics Biotech Inc > Pfizer acquires Canadian Trillium for US$2.3 Billion
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Comment by Noteableon Aug 23, 2021 10:21am
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Post# 33748033

RE:RE:Pfizer acquires Canadian Trillium for US$2.3 Billion

RE:RE:Pfizer acquires Canadian Trillium for US$2.3 BillionCD47 deals about T cells being able to infiltrate the tumor. Infiltration of two types of immune cells, CD8 T-cells and macrophages has been demonstrated to happen with CD47 antibody therapy,which ONCY has also been able to demonstrate with pelareorep. Furthermore, since pelareorep is able to convert an immunosuppressive TME into a more conducice environment that results in the  "priming" of the the adaptive immune system and traffick T-cells to the tumor cell surface and trigger T-cell infilitration into the tumor cell, ONCY's OV pelareorep works to facilitate CD47 antibody therapy and bispecific antibody therapy by preparing the TME and bringing these therapies to the tumor cell surface for activation.

https://www.fiercebiotech.com/research/asco-boehringer-ose-offer-promising-glimpse-immuno-oncology-drug-at-heart-their-1-4b-deal
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