Guidelines new injectable ARTs Paul mentioned the injectable ART drugs are for many are the preferred method of getting treated among MDR patients however the new monthly injectable drug mentioned below seems to have to fulfil few requirements before administration.
“With regard to patient preference, recommendations focus on the need to thoroughly discuss several critical requisites with potential candidates, including a 4-week lead-in daily oral ART course (CAB [Vocabria] 30 mg, RPV [Edurant] 25 mg) before initiating a loading dose. Patients should be advised of the potential for development of resistance should dosing be interrupted for any reason (CAB and RPV have extended half-lives ranging from mean 5.6-11.5 weeks for CAB and 13-28 weeks for RPV), as well as the need to return to oral bridging therapy if subsequent injections are not administered within the 7-day window period. If the maintenance dose is delayed beyond 2 months, a loading dose and restart is necessary.
Prior resistance testing, ART treatment history, and/or baseline genotypic resistance testing that includes both reverse transcriptase and integrase genes should be reviewed or conducted before initiating treatment. K103 mutations alone are not considered exclusionary. Virologic failures (defined as two consecutive plasma HIV-1 RNA measurements > 200 copies/mL), while rare, were reported in 13 clinical trial participants. Recent datasuggest that patients who developed resistance despite adherence had at least two of three factors: a body mass index > 30 kg/m2, the HIV-1 subtype A6/A1, and the presence of proviral RPV RAMS.”
https://www.medscape.com/viewarticle/955886