Non optimized vs optimized 1st 12 patients undertreated by 39-85% yielded a 25% CR or 3 patients at 90 days
6 optimized treated patients yielded 67% or 4 out of 6 patients and maybe would have been 5 as one patient died after negative urinate cytology.
Hence Optimized is about 2-4 Times as likely to get CR at 90 days. IMO