RE:Dose escalationSo, in theory, we are into another cycle at a higher dose of TH1902 now, this is equivalent 2.4 times the MTD of docetaxel alone. It seems that the previous dose, at almost two times the MTD was of docetaxel alone, was not toxic enough to be the MTD of TH1902. All this is very good, in theory, still it is not a proof of concept.
jfm1330 wrote: Then, if they get there, it would be 558.6 mg/m2 on September 7, and 742 mg/m2 on October 5. This would be a bit higherthan three times the MTD of free docetaxel, which is what they saw on rats in the preclinical.