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ProMIS Neurosciences Inc PMN

ProMIS Neurosciences Inc. is a clinical-stage biotechnology company. It is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). Its proprietary target discovery engine applies a thermodynamic, computational discovery platform-ProMIS and Collective Coordinates-to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product candidates are PMN310, PMN267, and PMN442. The PMN310 is a monoclonal antibody designed to treat AD by selectively targeting toxic, misfolded oligomers of amyloid-beta. PMN267 product candidate targeting ALS. PMN442 is a drug candidate being developed for MSA designed to selectively target and protect against pathogenic a-syn species.


NDAQ:PMN - Post by User

Comment by Gbathaton Sep 10, 2021 8:48pm
210 Views
Post# 33844310

RE:RE:PMN is top headline at alsnewstoday.com !

RE:RE:PMN is top headline at alsnewstoday.com !This is impressive stuff....

"Because conventional antibodies have a hard time entering cells, ProMIS developed intrabodies targeting that same protein region. These antibodies are not delivered directly to cells, but their genetic sequence is, allowing cells to produce their own antibodies.

Results so far have shown that exiting protein aggregates were cleared with these intrabodies (a type of antibody acting within a cell), while normal forms of the protein were preserved, and the spreading of clumps from one cell to another was inhibited."

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