Docetaxel resistance mechanisms https://www.sciencedirect.com/science/article/pii/S0753332221006065
The article talks about EMT- mediated metastasis. I think there is a link with the Sortilin receptor and Progranulin.
"In addition, we have observed an increase in protein expression of the transcription factors SNAIL (SNAI2) and SLUG (SNAI1) in progranulin-treated breast cancer cell lines (Additional file 2) suggesting that progranulin also increase epithelial-mesenchymal transition (EMT) features of breast cancer cells."
Also from the original article are suggested ways to overcome docetaxel resistance.
" The final strategy is brining bioengineering to the help of biology. To date, different kinds of nanocarriers have been developed for delivery of DTX in cancer therapy and enhancing its intracellular accumulation"