RE:Interesting read Using PDT to fight COVID 19Thanks Infinity. That was a very interesting and readable review article. It's notable that a woman from
Lahore College for Women University got top billing in this team from Pakistan. We may have to get used to a couple more acronyms as photodynamic therapy enters the anti-pathogen arena.
"PDT is a unique technique to kill various pathogens, including bacteria, fungi, viruses, and parasites.29 Therefore, PDT is called photodynamic antimicrobial chemotherapy (PACT) and photodynamic inactivation (PDI)" It was nice to see the mention of sonodynamic therapy which has greater depth of penetration but less potency than PDT. Dr. McFarland may be researching this technique to a greater extent in the future,
Sonodynamic Therapy: Analogous therapeutic approach
Sonodynamic therapy (SDT), a specific type of PDT, uses ultrasound as a light to activate PS. Of note, ultrasound penetrates the deep tissues to irradiate sensitizer molecules.112 In addition, ultrasound causes the poration phenomenon of the cell membrane, termed sonoporation.113 Previous studies have shown that SDT combined with PS, such as porphyrin xantene, TiO2, and fluoroquinolone antibiotics, effectively inactivate bacteria.114,115 Other data indicates that SDT eradicates bacteria, viruses, parasites, and other microbial entities.112 However, there are no reports available on whether SDT inactivates the SARS-CoV-2 virus.
Infinity wrote: Source: https://www.xiahepublishing.com/2572-5505/JERP-2020-00036 Abstract
Photodynamic therapy (PDT) for the inactivation of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) might be a valuable therapy for the treatment of coronavirus disease 2019 (COVID-19) disease. The spread of the SARS-CoV-2 virus has caused the COVID-19 pandemic, resulting in the death of many people worldwide due to the lack of effective treatments. FDA has recently approved two mRNA-based vaccines for emergency use, but still vaccine supply is limited. Therefore, it is imperative to discover new therapeutic strategies for the management of COVID-19 patients. PDT has been used to deactivate microorganisms for many years and might be an effective and promising therapy for COVID-19 patients. The PDT procedure is composed of a photosensitizer, light, and oxygen, which generate a local spurt of reactive oxygen species that can inactivate enveloped viruses and microorganisms. PDT is a safe, faster, cost-effective, and simple method to inactivate microorganisms. In addition, there have been no reports of resistance, unlike other antibiotics and antiviral drugs. This review aims to update the advancement of PDT and the findings could attract clinical attention in future clinical trials.