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Theratechnologies Inc T.TH

Alternate Symbol(s):  THTX

Theratechnologies Inc. is a Canada-based clinical-stage biopharmaceutical company. The Company is focused on the development and commercialization of therapies addressing unmet medical needs. It markets prescription products for people with human immunodeficiency viruses (HIV) in the United States. The Company's research pipeline focuses on specialized therapies addressing unmet medical needs in HIV, nonalcoholic steatohepatitis (NASH) and oncology. Its medicines include Trogarzo and EGRIFTA SV (tesamorelin for injection). Trogarzo (ibalizumab-uiyk) injection is a long-acting monoclonal antibody which binds to domain 2 of the CD4 T cell receptors. EGRIFTA SV (tesamorelin for injection) is approved in the United States for the reduction of excess abdominal fat in people with HIV who have lipodystrophy. Its portfolio includes Phase I clinical trial of sudocetaxel zendusortide (TH1902), a novel peptide-drug conjugate (PDC), in patients with advanced ovarian cancer.


TSX:TH - Post by User

Comment by palinc2000on Oct 01, 2021 12:41pm
138 Views
Post# 33952737

RE:RE:RE:RE:RE:RE:RE:Examples of efficacy from dose escalation studies

RE:RE:RE:RE:RE:RE:RE:Examples of efficacy from dose escalation studiesThere has not been a single quote  from Paul in which he hints that the Phase 1 will be successful.This small trial the first using Thera s PDC in humans is ongoing ,,Even though it is an open label trial I dont think Paul can determine the outcome be it negative or positive. He might feel optimistic and he should ,,otherwise why undertake a Clinical Trial if you dont think it has a chance of success even if the odds of non success are high....We need to let this pay out and making claims that Paul s credibility will suffer if patients in the trial dont react like the rats did in the pre clinical is ludicrous


qwerty22 wrote:

I'm not sure it's a question of him being truthful or not. Everything Paul is doing is normal. He has to believe in the tech and when he's talking about the potential inevitably he's going to focus on the positives. When he's projecting forward he has to talk about the many places the program might go. I think it's also totally normal not to talk about what's happening in the present with the patients. Also he has never over-sold what this first small trial can achieve. I think some of us (including me) may have got our expectations up too much. I definitely think Wino is expressing the right balanced approach atm.

If the data disappoints it's not going to be because Paul lied, it'll be because one of a dozen things that happened in the lab or in mice couldn't be reproduced in humans. I'm not expecting that, I'm expecting PoC, I'm hoping the data can deliver PoC and a bit more. We will see.

 

SPCEO1 wrote: Below is a more comprehensive quote from my post which I believe better characterizes what I was saying than just the portion you quoted. Do you think that the way Paul has characterized the cancer phase 1a so far can't be described as optimistic? Granted he has given us no actual data on the phase 1a but he has clearly built expectations of a positive result with pretty effusive comments. Here is what I posted earlier: Let's hope they do better this time around, regain their credibility and move onto many bigger and better things. If they have nothing in cancer to "tout" as Paul said yesterday, then Paul's credibility is going to fall another few notches lower since he has been consistently very positive in the way he has generally characterized the cancer phase 1a trial. Hopefully, the specific data coming from the trial, whenever they get around to telling us more, will back up those favorable comments. On the issue of what data they may already have, if there was a response when they were doling out lower doses to the patients, as the pre-clinical work suggested there would be, they would already know that. One issue, however, is did those earlier patients who were treated with lower doses survive long enough to have enough treatments to show an effect. My sense at the cancer KOL was that they had already begun to see some efficacy signals and the talk about wanting to rpove such things up in the right way also indicates they have seen something. Or they are just speking in an optimisitc manner that intentionally is creating a perception of success in the trial when no success has yet been seen? While they have shown a willingness to distort the truth in the past, I am hoping they learned from those mistakes.

 

palinc2000 wrote: Spceo wrote
Or they are just speking in an optimisitc manner that intentionally is creating a perception of success in the trial when no success has yet been seen? While they have shown a willingness to distort the truth in the past, I am hoping they learned from those mistakes. " 

I must have missed the optimism about clinical results in Oncology.All I heard is optimism on  the potential of the Platform in treating cancer IF clinical results are similar to pre clinical results....

 

 




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