Cardiovascular disease in PLWH “What was associated atherosclerosis was length of time living with HIV itself. For every 5 years a person lived with HIV, the study found the risk of having any atherosclerosis increased 20% and severity increased 23%. In addition, being a man was associated with a nearly 2.5-times increased risk of having any atherosclerosis and a 96% increased chance of having more severe atherosclerosis. Having diabetes was associated with a nearly threefold increased risk of atherosclerosis, as was every additional decade of life for a person who was living with HIV.
It’s important in that it’s a huge study that’s confirmatory [of] what we know, which is that there are high levels of subclinical coronary artery disease in people living with HIV, said Steven Grinspoon, MD, professor at Harvard Medical School in Boston, Massachusetts, and principal investigator of REPRIEVE.
As for the lack of association between abacavir and cardiovascular risk, he said he’s taking the findings with a grain of salt.
t’s hard to make a lot out of that, he said. It’s hard to know in a cross-sectional study. People put people on different things.”
As a reminder Dr. Stanley is currently studying Tesamorelin and it’s therapeutic effect on patients with NAFLD and cardiovascular risks.
https://themedicalprogress.com/2021/11/05/more-than-half-of-people-living-with-hiv-have-coronary-plaque/