"The coronavirus disease 2019 (COVID-19) has been shown to involve the gastrointestinal tract, which implies bacterial translocation and endotoxemia. The aim of this study was to evaluate the role of extracorporeal endotoxin removal by Polymyxin B hemoperfusion (PMX-HP), in the treatment of patients with COVID-19 and secondary bacterial infection....In a series of consecutive COVID-19 patients with endotoxic shock, PMX-HP was associated with organ function recovery, hemodynamic improvement, and contemporary EAA level reduction. No PMX-HP-related complications were observed."

https://read.qxmd.com/read/33377184/polymyxin-b-hemoperfusion-in-coronavirus-disease-2019-patients-with-endotoxic-shock-case-series-from-euphas2-registry





"These cases indicate that PMX-DHP therapy might be a suitable treatment option for dyspnea and deoxygenation in COVID-19 pneumonia..."

https://read.qxmd.com/read/33854342/pmx-dhp-therapy-for-dyspnea-and-deoxygenation-in-severe-covid-19-pneumonia-a-case-series





"We demonstrated the clinical improvement of severe COVID-19 patients with elevated EAA level upon receiving EA therapy."

https://read.qxmd.com/read/33857940/endotoxin-adsorbent-therapy-in-severe-covid-19-pneumonia




"This case indicates that adding polymyxin B immobilized fiber direct hemoperfusion to tocilizumab administration may further increase efficacy in coronavirus disease 2019 treatment"

https://read.qxmd.com/read/33796310/tocilizumab-and-pmx-dhp-have-efficacy-for-severe-covid-19-pneumonia




"On day 14 after the first treatment, disease severity decreased in 58.3% of the patients"

https://read.qxmd.com/read/33325084/direct-hemoperfusion-using-a-polymyxin-b-immobilized-polystyrene-column-for-covid-19




"...these attempts appeared to dampen the cytokine storm based on the observed decline in serum IL-6 levels and were effective against ARDS and secondary haemophagocytic lymphohistiocytosis. This case suggests the significance of timely initiation of extracorporeal treatment approaches in critically ill patients with COVID-19."

https://read.qxmd.com/read/33011959/continuous-extracorporeal-treatments-in-a-dialysis-patient-with-covid-19



"Two days of polymyxin B-immobilized fiber column-direct hemoperfusion (PMX-DHP) with adjunctive corticosteroid prevented his respiratory condition from worsening. For rapidly progressive COVID-19 cases, the early use of PMX-DHP may avoid the need for mechanical ventilation by suppressing local inflammation of the lung."

https://read.qxmd.com/read/32863364/successful-recovery-from-covid-19-associated-acute-respiratory-failure-with-polymyxin-b-immobilized-fiber-column-direct-hemoperfusion


SO far > 4 million people have died from Covid-19.   How many of these deaths involved Endotoxemia and Sepsis?

There are no signs that Covid-19 is easing up.  Infections are on the rise again in many parts of the world.




MM