RE:RE:Another Target Expression Comparison: Trop-2It is in the fourth section (Discussion) in their paper published in Cancer Science May 2021. It's the second to last paragraph in the whole paper. They mention that Sort1 was "upregulated" in around 60% of TNBC subtypes while PD-1 was upregulated in only 19% of TNBC. THTX's 60% in TNBC is from the paper by Roselli & Pundavela (Oncotarget 2015, Sortilin is assoc with breast cancer aggresiveness...". The PD-1 stat is from Sun, Lee "Expression of PD-L1 in TNBC based on different immunohitochemical antibodies. J Transl Med 2016.
Love it if you can find more definitive stats like that around other tumor types and other targets being used for cancer treatements.
jfm1330 wrote: Where did Thera release that info?
Wino115 wrote: So we learned from THTX that sortilin overexpression is 3x that of PD-1 (Keytruda's target) in tumors.