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Spectral Medical Inc T.EDT

Alternate Symbol(s):  EDTXF

Spectral Medical Inc. is a Canada-based late-stage theragnostic company advancing therapeutic options for sepsis and septic shock. The Company develops and commercializes a treatment for septic shock utilizing its Endotoxin Activity Assay (EAA) diagnostic and the Toraymyxin therapeutic (PMX). PMX is a therapeutic hemoperfusion device that removes endotoxin, which can cause sepsis, from the bloodstream and is guided by the Company’s EAA. PMX is approved for therapeutic use in Japan and Europe and has been used safely and effectively on more than 340,000 patients to date. It has pioneered the development of biochemical markers for the clinical syndrome known as septic shock. It is continuing its legacy business of manufacturing and selling certain proprietary reagents. It develops, produces and markets recombinant proteins, antibodies and calibrators. These materials are sold for use in research and development, as well as in products manufactured by other diagnostic companies.


TSX:EDT - Post by User

Post by mercedesmanon Dec 01, 2021 1:50pm
214 Views
Post# 34186071

Sell... now if...

Sell... now if......you believe, as the market seems to believe (based on the current SP) , that there is almost ZERO (lets call it 2%) probablity of approval of PMX by the FDA.

This despite:
  • Phase 3B Trial being labelled "confirmatory" meaning they just have to reach the "meh" goals of Euphrates, but now armed with much better data and selection criteria.
  • indications from Mgt that the Tigris Trial, so far, is "exceeding expectations".
  • Favourable Trial paramaters granted by the FDA (Open label, Bayesian, 2:1)
  • likely far greater need now (Covid leads to Sepsis - see gut dysbiosis and endotoxemia in advanced/severe Covid patients)
  • 300,000 safe uses world-wide
  • Meta analysis data with 10's of thousands of participants supporting a PMX mortality benefit. 
  • Euphas 2 (early Trial stoppage for efficacy reasons)
  • Euphas Registry ( closing in on another decade of gathered evidence and proof)
  • PMX being supported by Ronco as a Golden Hour sequential therapy.  (Ronco is likley the world's leading authority on Sepsis, and AKI)
  • Kellum joins Spectral in 2021 (jettisoning all other ties with other co's including HP co's) Loads up on options and shares all above .425
  • mounting RWE evidence in support of PMX, and not just for Sepsis
  • it is backed by a multi billion dollar Japanese congolmerate
  • it has a distribution agreement with a multi-billion dollar Company that owns the ICU supply market.

And also sell, if despite all of the above, you believe that all of the following assets/pieces are totally worthless  to other market players as well:
  • Dialco = virtually worthless.  Even though it is likely (it's a question of when not if - per Seto)  to be the 3rd or 4th entrant in the about to greatly expand, HD market, with Diaco's entrant, offering "ground breaking" new technology
  • never mind that the first two entrants into the HD market, have captured a market cap of $ 2B USD for their Home Dialysis machine only
  • never mind that DIMI will smash most if not all barriers to adoption that the competition does not.
  • the FDA approved EAA is worthless despite its utility (at the very least) as a ICU triage tool to rule out Sepsis. And with worldwide exclusive rights to boot.
  • $ 80 million in past Trial costs, and acquired IP has no utility to other biotechs  (e.g. even just as a a tax loss shelter)
  • That they have valueless world wide & patented rights to the only HP pump on the market (SAMI) = utility for the Golden Hour sequntial therapy approach advocated by Ronco


MM

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