Oncolytics Biotech Inc T.ONC

Roche's I/O TIGIT + Tecentriq combo effective .. BUT ...

[Noteable]

' New follow-up data for Roche’s Tecentriq-tiragolumab combination therapy in certain lung cancer patients have analysts sighing in relief that the anti-TIGIT element appears to be pulling its weight, but two deaths in the combination arm hit the company's shares Friday morning.'

Safety data weren't clean, however, as there were two grade 5 events—which in trial speak means deaths—specifically both from the combo arm of the trial. The two treatment-related deaths were the results of pyrexia—or fever—and infection, according to detailed data presented at the European Society for Medical Oncology Immuno-Oncology virtual congress. Shares were off nearly 1% in early premarket trading on this update, taking the shine off the data.

Roche is fighting with Merck—and, further back, Bristol Myers Squibb—to make TIGIT work big in cancer, with checkpoint inhibitor combos appearing to be the way to go for both pharmas.

https://www.fiercebiotech.com/biotech/roche-posts-impressive-tigit-combo-lung-cancer-data-as-jefferies-read-blockbuster-sales-tea