Reovirus for the treatment of multiple myeloma
Reovirus-induced cell-mediated immunity for the treatment of multiple myeloma within the resistant bone marrow niche
Taken together, these findings demonstrate that reovirus treatment of MM cells can generate MM-specific CTLs capable of killing MM cells, even when they reside in a protective BM niche.
data suggest that induction of antitumor immunity by an OV can overcome stromal-mediated tumor resistance—a key mechanism by which MM cells escape chemotherapeutic control and give rise to relapse.
https://jitc.bmj.com/content/jitc/9/3/e001803.full.pdf