Claritas Pharmaceuticals Inc V.CLAS.H

RE:Sad but true.

[AngelaL]

There is of course a vast literature on the nitric oxide pathway in sexual dysfunction. Viagra, for example, works by stabilizing cGMP which is induced by endogenous nitric oxide. For female sexual dysfunction there is also a growing scientific literature, since the erectile function of the clitoris and the lubrication of the vagina are mediated by endogenous nitric oxide stimulation of cGMP. I have not seen any published work for R-107 in female sexual dysfunction but there are a number of published studies that have looked at other exogenous organic nitrates (eg NTG) and have observed dramatic effects on mucosal blood flow, clitoral engorgement, and vaginal secretion. The female sexual dysfunction market is relatively young but is growing. It would not be surprising if R-107 is highly effective in this setting. Thanks for starting the discussion on this topic. It is important.