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ProMIS Neurosciences Inc PMN

ProMIS Neurosciences Inc. is a clinical-stage biotechnology company. It is focused on generating and developing antibody therapeutics selectively targeting toxic misfolded proteins in neurodegenerative diseases such as Alzheimer’s disease (AD), amyotrophic lateral sclerosis (ALS) and multiple system atrophy (MSA). Its proprietary target discovery engine applies a thermodynamic, computational discovery platform-ProMIS and Collective Coordinates-to predict novel targets known as Disease Specific Epitopes on the molecular surface of misfolded proteins. Using this approach, the Company is developing novel antibody therapeutics for AD, ALS and MSA. Its product candidates are PMN310, PMN267, and PMN442. The PMN310 is a monoclonal antibody designed to treat AD by selectively targeting toxic, misfolded oligomers of amyloid-beta. PMN267 product candidate targeting ALS. PMN442 is a drug candidate being developed for MSA designed to selectively target and protect against pathogenic a-syn species.


NDAQ:PMN - Post by User

Comment by M101on Jan 12, 2022 4:45pm
148 Views
Post# 34310242

RE:RE:RE:RE:Aduhelm stimulation

RE:RE:RE:RE:Aduhelm stimulation btw, I assume you've looked at this week's conference presentation, so if you understood it you should be asking wtf is holding this back? Gene mentions Acumen, the financing there alone shows how ridiculously undervalued PMN is given the claimed advantages we have.  
https://www.promisneurosciences.com/news-media/events/detail/8684/h-c-wainwright-bioconnect-2022-virtual-conference

So is it that the market doesn't believe in toxic misfolded proteins as root cause hypothesis, or doesn't know about the company, or doesn't trust the management?

I thought the presentation was impressive but we've seen all before so we know it will have no effect on the market. I commend Gene for finally getting past Aducanumab, almost, as it has been his security blanket for several years. But he still can't bring himself to criticize it in any way, even with the crooks at Biogen now flailing to squeeze some value out of it at the expense of Medicare (which the industry wants to bankrupt anyway). 

And this brings up the competition going forward: Lily's Donanemab, Biogen/Esai's Lecanemab/Ban2401, and Acumen's ACU193:  
Is Gene going to pander to his peers again, or is he going to say something bold that media can latch onto for his shareholders? 
What would JFK say about before this decade is out...? 





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