Alzheimer's-like changes found in COVID patients' brains; .. Alzheimer's-like changes found in COVID patients' brains; flu shot, mRNA booster safe together
Alzheimer’s-like changes seen in COVID-19 patients’ brains
People who die of severe COVID-19 have brain abnormalities that resemble changes seen in Alzheimer’s disease - accumulation of a protein called tau inside brain cells, and abnormal amounts of the protein beta-amyloid that accumulates into amyloid plaques - small studies have found.
At Columbia University, Dr. Andrew Marks and colleagues studied the brains of 10 COVID-19 patients and found defects in proteins called ryanodine receptors that control the passage of calcium into cells. In Alzheimer’s disease, defective ryanodine receptors are linked to accumulation of tau into so-called neurofibrillary tangles. These tangles were present in high levels in the COVID-19 patients’ brains, the Columbia team reported on Thursday in Alzheimer’s & Dementia. Other research teams have looked for - and found - abnormal amyloid levels in brains of COVID-19 patients, according to reports posted online ahead of peer review on bioRxiv and on The Lancet’s preprint server.
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