RE:RE:RE:RE:RE:TLT Filling Up With Cash Great news today....& fortunately things are calming down on the Pandemic front, which should help with enrollment. I also agree that 2023 is a realistic timeframe.
I found the following comment in today's NR intriguing...
'Further research by UM also identified that the spike protein responsible for the transmission of a coronavirus into a host cell, remained intact after light-activated TLD-1433 inactivation, suggesting that the vaccine developed by this technology could potentially stimulate a protective antibody immune response in a mammalian host."
The key to an effective inactivated vaccine is the preservation of the primary viral component (the epitope/spike protein in this case) once the virus is inactivated. It is this primary epitope that can elicit a more effective neutralizing immune response. Preserving a key epitope during the inactivation process is certainly not a given...as various agents used in this process can often change/destroy the primary epitope. The fact that the light-activated TLD-1433 was able to preserve the spike protein in full after 99.99% inactivation is a "big deal" imo. It not only indicates incredible potential as a preventative against multiple virus types, it also opens the door for its potential use as a therapeutic. Another thought...it is also possible that during the inactivation process, other potential antigens (i.e. damage-associated molecular patterns, etc.) could be unleashed that could serve as a vaccine adjuvant to further boost the immune response...?
Such a versatile compound/tech is bound to bring good news for many years to come...GLTA.