RE:RE:WowThese genetic test look for mutations related to cancer, they cannot tell you the expression level of a normal protein like sortilin. What they can do, in some cases, is to avoid a given chemotherapy drug, or chose one that will work. Here in Quebec it is available for free for pediatric cancers. Maybe some adults can also have it for free. But you can pay to have it from a private company, but you also need a biopsy. To me the best way to do a personalized treatment with TH19P01 based PDC would be to develop an imaging PDC for PET scans which would be TH19P01-DOTA-Ga68. I know I said it many times here, but it seems so obvious. It does not only allow to see if sortilin is overxpressed.It allows to see the PDC binding with the tumors and also distribution in other organs. If they achieve proof of concept, they need to develop that. It would be easy and quick. They have all the building blocks, and Gallium 68 has a track record of use in humans. So its toxicity is well known, and with the newest PET scanners, the needed injected dose to get good images is much lower than before.
Wino115 wrote:
By the way, in the KOL transcript for the Ovarian Endo talk I posted about, the doctor said that it's now pretty standard at Mass General that they run a tumor sample genetic test and know all the various genetic expression levels prior to talking about any treatment options. She made it sound like that was more or less standard now at any cancer oriented hospital setting. I may be wrong, but wouldn't that be where you'd find Sort1 levels too, as opposed to staining?