RE:RE:RE:RE:Upcoming patient data
Another interesting thing about the above graph of durable response (bcg+n-803) is that they hit 55% at 18 months but to my eyes it drops off another few steps so by 27 months it is around 25%. For these kind of graphs you get used to them leveling off as everyone who is in true remission stays that way. To have it keep dropping off makes me think that the CR isn't really a CR in a cure sense. If it were a "complete" response it wouldn't be coming back so much. I know that CR is defined by cytology and scope imaging but if I had bladder cancer, I wouldn't feel cured if you told me, at 18 m, that there was only a 50% chance of me going further as a CR. TLD-1433 on the other hand, one treatment for some and years of no recurrence (consider the 2 phase 1b patients that are still CR after one treatment way back).
So yes, impressive response but I have a hard time thinking of the response as durabe if it keeps falling off even after 24months. IMO