RE:Marsolais said ´300 is a VERY GOOD dose More ftom the transcripts
Okay, on TH1902, again, how serious were the adverse events in the cycles after the initial cycle?
Paul Levesque
Christian?
Christian Marsolais
Yeah, what we've seen is our adverse events are linked to when you get a higher dose of docetaxel. At some point you get [indiscernible] or go higher to a certain level. And what you see with docetaxel, they seem the same after two or three cycles. That's what the signs of neurotoxicity that's seen with those docetaxel. We've seen also some signs on visual acuity seen with docetaxel and some fatigue. Then we have regular discussion with all of the investigator taking part in this study on based on that observation, we decided to build to this 300 mg/m2 where we think that even if it's at 1.5 times a dose of docetaxcel, it will be much better tolerated and will be able to give way more cycle, a the 200 mg/m2, which is the objective in treating advanced cancer patients.
palinc2000 wrote: Here are his exact words from the transcripts
Christian Marsolais
Yeah, what we mentioned is that we have seen some monthly DLT [indiscernible] in 420 mg/m2. We reduced the dose to 300 20 mg/m2, which is 1.5 times the dose of docetaxel but given were administered alone, then this is a very good dose. And now we're proceeding with this study enrolling three patients looking at DLT and is following three patients. After that, we'll be ready to open the basket trial. At this stage, based on the data that we have, we're not expecting any DLTs of 300 but that will be known in the next two, three months.